Regenerating Wnts
نویسندگان
چکیده
منابع مشابه
Regenerating Wnts
Research in recent years challenged what we once thought of as the canonical function of signaling proteins to reveal new and surprising mechanisms of action. Morphogens, like Wnts, BMPs, or SHHs, long thought to be the factors that provide positional information to specify cell fate and proliferation have turned out to be as important for synaptogenesis, axonal growth, and guidance during both...
متن کاملWhen Wnts antagonize Wnts
Secreted Wnt ligands appear to activate a variety of signaling pathways. Two papers in this issue now present genetic evidence that "noncanonical" Wnt signaling inhibits the "canonical" Wnt/beta-catenin pathway. Westfall et al. (2003a) show that zebrafish embryos lacking maternal Wnt-5 function are dorsalized due to ectopic activation of beta-catenin, whereas Topol et al. (2003) report that cho...
متن کاملThe Wnts
How do Wnts work? Developmental and cancer biologists have feverishly dissected the mechanism of Wnt signal transduction (see Figure; homologous vertebrate/invertebrate proteins are indicated in the legend). The prevailing dogma is that the Wnt signal causes β-catenin/Armadillo to accumulate in the nucleus where it acts together with the transcription factor TCF/LEF/Pangolin. But this might not...
متن کاملGastrulation: Wnts Signal Constriction
Recent work shows that Wnt signaling directly regulates the apical constriction that drives gastrulation movements in Caenorhabditis elegans, and also promotes invagination in sea urchins, providing a novel and possibly conserved mode of developmental regulation.
متن کاملSecretion of Wnts is dispensable for hematopoiesis.
In this issue of Blood, Kabiri and coworkers report the hematopoietic deletion of the endoplasmic reticulum–localized O-acyltransferase porcupine (PORCN), which is necessary for acylation of Wnts in the endoplasmic reticulum, enabling their secretion and binding to the frizzled receptors. Unexpectedly, the absence of secreted Wnt factors does not have major effects on steady-state in vivo hemat...
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ژورنال
عنوان ژورنال: Frontiers in Molecular Neuroscience
سال: 2012
ISSN: 1662-5099
DOI: 10.3389/fnmol.2012.00043